Hey Filippo,
Currently, Vapi’s servers are based in the US, so being closer to the US generally results in better latency. For telephony, however, the impact is minimal. If you choose a server in Europe, the user-to-Twilio latency may decrease, but the Twilio-to-Vapi latency will increase, making the overall difference negligible. Although it may provide a slightly better experience for the user.
For voice calls, this usually doesn’t have a significant effect. However, for TTS, STT, or LLM interactions, it’s recommended to be based in the US, as server-to-server communication will be faster and most providers have readily available infrastructure there.
You may experiment with both if in you can, Vapi provide latency report with calls so you can easily compare.