Yeah @Sean from my experience and from what most people report, Telnyx usually gives better audio quality and lower latency in the USA, especially for AI voice agents and SIP setups. Twilio is still solid and more mature ecosystem-wise, but Telnyx tends to feel more natural/cleaner because of their private backbone routing.
That said, setup/configuration also matters a lot codecs, regions, transcoding, and your provider routing can make a huge difference. I’ve worked with both and can help you test/A-B compare them properly for your use case.